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Clinical electron microscopy (EM) is a technique which performs ultrastructural studies on tissues and obtains high resolution images greatly superior to light microscopy.
It is an essential tool for daily practice of renal pathology by providing an additional and complementary study of the other two modalities (light microscopy and immunofluorescence). Certain renal diseases such as thin glomerular basement membrane disease, minimal change disease, Alport syndrome, are impossible to be diagnosed without EM. Of note, this method provides further value in detecting early amyloidosis in adipose tissue and in diagnosing cilia disorders, storage diseases, and infectious diseases. EM can also be used to aid in the diagnosis of neurological, muscular, and dermatologic diseases. Overall, EM can help in the most challenging anatomic pathology cases.
The electron microscopy (EM) laboratory is CLIA licensed provider in both clinical and research settings. The EM lab offers transmission electron microscopy and operates as a core facility of the Miami Project to Cure Paralysis.
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