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Research Publications Fiscal year 2019-2021

  1. Vijay Thakur and *Scott M. Welford.* Generation of a conditional mutant knock-in under the control of the natural promoter using CRISPR-Cas9 and Cre-Lox systems. PLoS One, 2020, in press.

  2. Rutulkumar Patel R, Luchang Zhang, Amar Desai, Mark J. Hoenerhoff, Lucy H. Kennedy, Tomas Radivoyevitch, Chiara La Tessa, Stanton L. Gerson, and *Scott M. Welford.* Protons and high-LET radiation induce genetically similar lymphomas with high penetrance in a mouse model of the aging human hematopoietic system. Int J Radiat Oncol Biol Phys. 2020 in press.

  3. Sze Kiat Tan and *Scott M. Welford.* Lipid in Renal Carcinoma: Queen Bee to Target? Trends in Cancer. 2020 in press.

  4. Raffaella Spina, Dillon M. Voss, Xiaohua Yang, Jason W. Sohn, Robert Vinkler, Julianna Schraner, Anthony Sloan, Scott M. Welford, Norbert Avril, Heather M. Ames, Graeme F. Woodworth, and Eli E. Bar. MCT4 regulates de novo pyrimidine biosynthesis in GBM in a lactate-independent manner. 2020 Neurooncology Advances. Jan-Dec;2(1):vdz062.

  5. Vijay S. Thakur, Brittany Aguila, Adina Brett-Morris, Chad J. Creighton, and *Scott M. Welford.* Spermidine/spermine N1-acetyltransferase 1 is a gene-specific transcriptional regulator that drives brain tumor aggressiveness. Oncogene. 2019 Aug 9. PMID: 31399646

  6. David Danielpour, Zhaofeng Gao, Patrick M. Zmina, Eswar Shankar, Benjamin C. Shultes, Raul Jobava, *Scott M. Welford,* and Maria Hatzoglou. Early Cellular Responses of Prostate Carcinoma Cells to Sepantronium Bromide (YM155) Involve Suppression of mTORC1 by AMPK. Scientific Reports. 2019 Aug 8;9(1):11541. PMID: 31395901

  7. Brittany Aguila, Adina Brett-Morris, Raffaella Spina, Eli E. Bar, Julie Schraner, Robert Vinkler, Jason W. Sohn, and Scott *M. Welford.* The Ig superfamily protein PTGFRN coordinates survival signaling in glioblastoma multiforme. Cancer Letters. 2019 Oct 10;462:33-42. PMID: 31377205

  8. Sunoqrot MRS, Selnæs KM, Sandsmark E, Nketiah GA, *Zavala-Romero O, Stoyanova R,* Bathen TF, Elschot M A, Quality control system for automated prostate segmentation on T2-weighted MRI, Diagnostics, in press

  9. *Delgadillo R, Ford JC, Abramowitz MC, Dal Pra A, Pollack A, Stoyanova R,* The Role of Radiomics in Prostate Cancer Radiotherapy, Strahlentherapie und Onkologie, in press

  10. *Zavala-Romero O, Breto AL, Xu IR, Chang YC, Gautney N, Dal Pra A, Abramowitz MC, Pollack A, Stoyanova R,* Segmentation of prostate and prostate zones using Deep Learning: a multi-MRI vendor analysis, Strahlentherapie und Onkologie, doi: 10.1007/s00066-020-01607-x. Online ahead of print (2020)

  11. *Pollack A, Chinea FM, Bossart E, Kwon D, Abramowitz MC,* Lynne C, Jorda M, *Marples B, Patel VN, Wu X,* Reis I, *Studenski MT,* Casillas J, *Stoyanova R,* Phase I Trial of MRI-guided prostate cancer lattice extreme ablative dose (LEAD) Boost Radiotherapy, Int J Radiat Oncol Biol Phys, 107(2): 305-315 PMID: 32084522 (2020)

  12. *Stoyanova R, Giret TM, Abraham S,* Ao Z, Williams A, *Udayakumar TS,* Torres-Munoz J, *Patel M, Breto AL,* Ramachandran K, Singal R, Datar R, Jorda M, Cote R, *Ishkanian A, Zeidan YH, Dal Pra A, Abramowitz MC, Pollack A,* Contrasting Circulating Tumor Cells and Free Circulating DNA Responses in Men Treated for Prostate Cancer after Primary Versus Salvage Radiotherapy, Clinical Oncology and Research, in press.

  13. Iakymenko OA, Lugo I, Kwon D, Zhao W, Hayee A, Punnen S, Parekh DJ, *Pollack A,* Ritch CR, Gonzalgo ML, Stoyanova R, Jorda M, Kryvenko ON, Prostatic Ductal Adenocarcinoma Controlled for Cancer Grade and Tumor Volume Does Not Have an Independent Effect on Adverse Radical Prostatectomy Outcomes Compared to Usual Acinar Prostatic Adenocarcinoma, Urology, 137: 108-114 PMID: 31711982 (2020)

  14. Jin S, Han S, *Stoyanova R,* Ackerstaff E, Cho H. Pattern recognition analysis of dynamic susceptibility contrast (DSC)-MRI curves automatically segments tissue areas with intact blood-brain barrier in a rat stroke model: A feasibility and comparison study, J Magn Reson Imaging, 51(5):1369-1381 PMID: 31654463 (2020)

  15. Lisa A. McPherson, Clara I. Troccoli, Debin Ji, Annie E. Bowles, Makelle L. Gardiner, Dao M. Nguyen, David J. Robbins, Nipun B. Merchant, Nagaraj S. Nagathihalli, Eric T. Kool, *Priyamvada Rai,* James M. Ford*. Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue. DNA Repair (Amst). 83:102644. doi: 10.1016/j.dnarep.2019.102644. (2019)

  16. Yi Zhu, Jiaqi Liu, Joun Park, *Priyamvada Rai,* R. Grace Zhai. Subcellular compartmentalization of NAD+ and its role in cancer: A sereNADe of metabolic melodies. Pharmacology and Therapeutics 200:27-41. doi: 10.1016/j.pharmthera.2019.04.002. (2019)

  17. Govindi J. Samaranayake, Clara I. Troccoli, Ling Zhang, Mai Huynh, Christina Jayaraj, Debin Ji, Lisa McPherson, Yoshiyuki Onishi, Dao M. Nguyen, David J. Robbins, Mahsa Karbaschi, Marcus S. Cooke, Antonio Barrientos, Eric T. Kool, *Priyamvada Rai.* The existence of MTH1-independent 8-oxodGTPase activity in cancer cells as a compensatory mechanism against on-target effects of MTH1 inhibitors. Molecular Cancer Therapeutics 19(2):432-446. doi: 10.1158/1535-7163.MCT-19-0437. (epub 2019) (*One of 64 articles short-listed by STAT News for most innovative biomedical research published in 2019)

  18. Blessing NW, Chen Y, Choi CJ, Kanokkantapong J, *Tao W,* Pelaez D, Lee BW.Orbital Hemorrhagic Necrosis, Globe Rupture, and Death From Intraorbital Injection of 1% Sodium Deoxycholate in a Murine Model. Ophthalmic Plast Reconstr Surg. 2020 Oct 8. doi: 10.1097/IOP.0000000000001850. Epub ahead of print. PMID:33060511. (2020)

  19. Zheng S, *Tao W.* Targeting Cullin-RING E3 Ligases for Radiosensitization: From NEDDylation Inhibition to PROTACs. Front Oncol. 2020 Aug 21;10:1517. doi:10.3389/fonc.2020.01517. PMID: 32983997; PMCID: PMC7475704. (2020)

  20. Lee JY, Gallo RA, Ledon PJ, *Tao W,* Tse DT, Pelaez D, Wester ST. IntegratingDifferential Gene Expression Analysis with Perturbagen-Response Signatures May Identify Novel Therapies for Thyroid-Associated Orbitopathy. Transl Vis Sci Technol. 2020 Aug 25;9(9):39. doi: 10.1167/tvst.9.9.39. PMID: 32908802; PMCID: PMC7453043. (2020)

  21. Zheng S, *Tao W.* Identification of Novel Transcriptome Signature as a Potential Prognostic Biomarker for Anti-Angiogenic Therapy in Glioblastoma Multiforme. Cancers (Basel). 2020 Aug 21;12(9):E2368. doi: 10.3390/cancers12092368. PMID: 32825640. (2020)

  22. Tse BC, Dvoriantchikova G, *Tao W,* Gallo RA, Lee JY, Ivanov D, Tse DT, Pelaez D. Mitochondrial targeted therapy with elamipretide (MTP-131) as an adjunct to tumor necrosis factor inhibition for traumatic optic neuropathy in the acute setting. Exp Eye Res. 2020 Oct;199:108178. doi: 10.1016/j.exer.2020.108178. Epub 2020 Aug 3. PMID: 32758490; PMCID: PMC7554259. (2020)

  23. Udayakumar TS, Betancourt DM, *Ahmad A, Tao W,* Totiger TM, Patel M, Marples B, Barber G, *Pollack A.* Radiation Attenuates Prostate Tumor Antiviral Responses to Vesicular Stomatitis Virus Containing IFNβ, Resulting in Pronounced Antitumor Systemic Immune Responses. Mol Cancer Res. 2020 Aug;18(8):1232-1243. doi: 10.1158/1541-7786.MCR-19-0836. Epub 2020 May 4. PMID: 32366674. (2020)