The Weinberger Lab is always open to collaborative projects with interested laboratories. We have established expertise in quantitative and synthetic analyses of cell-fate circuits in viruses and other systems.
The lab's particular strengths lay in:
- Quantitative time-lapse microscopy (of gene expression and of viral infections)
- Construction and design of synthetic fate-selection circuits
- Design of novel cell-based therapeutic screens
- Modeling & simulation of infection dynamics across multiple scales (single cell, patient, and epidemiological scales)
- Viral latency & evolution
Below are some examples of our most recent collaborations and publications with other investigators.
Recent Collaborative Projects
Michael L. Simpson, Ph.D., University of Tennessee, Knoxville and ORNL
- An Endogenous Accelerator for Viral Gene Expression Provides a Fitness Advantage. Cell.
- Transcriptional burst frequency and burst size are equally modulated across the human genome. PNAS
- Transcriptional bursting from the HIV-1 promoter is a significant source of stochastic noise in HIV-1 gene expression. Biophys J.
- Transient-mediated fate determination in a transcriptional circuit of HIV. Nat Genet.
- The Low Noise Limit in Gene Expression. PLoS ONE
Michelle Arkin, Ph.D., University of California, San Francisco
Ariel Weinberger, Ph.D., Wyss Institute Harvard University
- An Evolutionary Role for HIV Latency in Enhancing Viral Transmission. Cell.
- The case for transmissible antivirals to control population-wide infectious disease. Trends in Biotechnology. Cell Press.
- Stochastic Fate Selection in HIV-infected Patients. Cell.
- Accelerated immunodeficiency by anti-CCR5 treatment in HIV infection. PloS Comput Biol.