Stroke Division Research Miller School of Medicine

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The Stroke faculty conducts cutting edge research to address a variety of cerebrovascular diseases. The division is actively enrolling patients in acute stroke treatment, stroke prevention and stroke recovery trials, and has special interest in stroke in minorities.

We are proud to announce that we are a member of the NIH StrokeNet Trials Network.

What is StrokeNet?

The National Institutes of Health created StrokeNet to conduct cutting-edge novel studies in acute treatment, prevention and recovery of Stroke, a consortium of 25 regional centers across the US, involving over 200 hospitals. The network collaborates to create, evaluate and prioritize novel ideas in the pipeline, rapidly complete these studies through expedited regulatory processes to bring needed treatments that will impact stroke care to the clinical arena, and to train the next generation of stroke researchers. It is anticipated that all Stroke studies funded by the National Institutes of Health will be conducted only at StrokeNet sites.

In collaboration with the University of Miami, we have formed a regional consortium in Florida as one of the 25 Regional Networks for StrokeNet and the only one in Florida. It includes acute care, pediatric and rehabilitation hospitals that leverage academic-private-community partnerships.

Currently Enrolling Research Studies

Our currently enrolling research

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Name of study	Short Name	Summary
A Phase III, Prospective, double-blind, randomized, Placebo-controlled trial of thrombolysis in Imaging-eligible, late-window patients to assess the efficacy and safety of tenecteplase	TIMELESS	The purpose of this study is to compare the effects, of tenecteplase versus placebo on patients that have stroke symptoms beyond 4.5 hour. In this study, participants receive tenecteplase or placebo, as well as the current standard of care for stroke. A placebo looks like a drug but has no active ingredient. This clinical trial is funded by Genentech.
Multi-arm Optimization of Stroke Thrombolysis Stroke	MOST	The main purpose of the MOST study is to examine the safety and the effectiveness of adding one of two blood-thinning medicines to standard treatment with tPA. The blood-thinning medicines are eptifibatide or argatroban. Both are FDA-approved blood thinners, but they are not approved for treating strokes. MOST is studying whether these medicines are safe and help stroke patients. The MOST study includes patients who have had strokes caused by a blood clot in their brain and are receiving standard treatments for stroke: a medicine used to try to dissolve a clot (tPA) or a device may used to try to remove the clot. Funded by NIH/NINDS.
Atrial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke	ARCADIA	This study compares the effects of the blood-thinner apixaban (also known as Eliquis®) with the effects of aspirin in patients with unexplained strokes and atrial cardiopathy to see which is better at prevention of future strokes. Funded by NIH/NINDS.
ARCADIA Cognitive function and Silent Infarcts	ARCADIA CSI	This is a research study looking to compare the effects of the ARCADIA study drugs (apixaban and aspirin) on the occurrence of silent strokes and memory loss after stroke. This add-on study to the ARCADIA trial involves cognitive testing (tests designed to measure memory, thinking, reasoning and understanding) and an MRI scan of the brain.
Sleep for Stroke Management And Recovery Trial	Sleep SMART	This study investigates whether treatment for sleep apnea, in people who have had a stroke or TIA, improves recovery from stroke, and helps prevent future stroke, heart problems, and death. The intervention being tested is called continuous positive airway pressure (CPAP). Funded by NIH/NINDS.
Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial	CREST-2	CREST-2 study compares carotid revascularization plus intensive medical management vs. intensive medical management alone in patients with asymptomatic high-grade carotid stenosis. Patients will be randomized in a 1:1 ratio to endarterectomy vs. no endarterectomy and the other study group will randomize patients in a 1:1 ratio to carotid stenting with embolic protection vs. no stenting. All study patients will receive medical management. Funded by NIH/NINDS.
Carotid Revascularization and Medical Management for Asymptomatic Carotid stenosis - Hemodynamics	CREST-H	This add-on study to the CREST-2 trial. The goal of this study is to determine if undergoing a procedure to open up a narrow carotid artery compared to medical management only improves thinking ability. CREST-H will study how blood flow to the brain affects short-term memory and organizing information in the brain. The study will assess both people who have, and do not have, reduced flow to the brain. Funded by NIH/NINDS.
Anticoagulation in Intracerebral Hemorrhage (ICH) Survivors for Stroke Prevention and Recovery	ASPIRE	The purpose of ASPIRE is to compare the effects of apixaban (also known as Eliquis®) with the effects of aspirin in patients with atrial fibrillation and a recent brain hemorrhage to see which is better in preventing future strokes and death. Funded by NIH/NINDS.
Statins use in intracerebral hemorrhage patients	SATURN	This research is being done to find out if it is better to continue or discontinue statin drugs in people who had a brain hemorrhage while taking a statin drug. This study is also being done to see if having one of the Apolipoprotein-E genes actually increases the risk of brain hemorrhage in people who take statin drugs. Funded by NIH/NINDS.
Transition of Care Stroke Disparity Study	TCSD-S	The purpose of TCSD-S is to find out the reasons why some people may be readmitted to hospital after being discharged to home, to inpatient rehabilitation, or to an Assisted Living Facility (ALF) including whether the recommendations that doctors made at the time of discharge play a role in being readmitted. By using that information, the investigators will identify the causes for readmission and develop educational programs to improve stroke outcomes and reduce hospital readmissions. Funded by NIH/NIMH.
Mechanisms of EarlY Recurrence in Intracranial Atherosclerotic Disease	MyRIAD	The purpose of this research study is to learn about the possible causes of stroke or TIA in individuals that have a narrowed brain artery. We will also try to find out if the brain’s ability to adjust the amount of blood supply to the portion of the brain supplied by a narrowed brain artery plays a role in the reappearance of stroke. Funded by NIH/NINDS.

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