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Research

Neurocritical Care Division

Research Team

  • Research Coordinator

  • Faculty

  • Fellows

  • Residents

  • Medical Students

  • Graduate Students

  • Undergraduate Students

Actively Enrolling Studies and Grants Funding

  • Detection of early biomarkers for post traumatic epilepsy (EpiBioS4Rx)- NIH/NINDS, Dr. O'Phelan (site PI). 
  • Detection of spreading depolarization acutely after TBI (SDII)- NIH/NINDS, Dr. O'Phelan (site PI).
  • Detection and prediction of recovery of consciousness in ICH patients (RECONFIG)- NIH/NINDS, Dr. Alkhachroum (site PI).
  • Electrophysiologic Biomarkers Of Consciousness Recovery after TBI (EBC study)- CTSI/KL2 career development award, Dr. Alkhachroum (study PI). 
  • The Miami traumatic brain injury registry - Dr. Alkhachroum (study PI).
  • The meditation study in spinal cord injury patients- Dr. O'Phelan (study PI). 
  • Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI)- NIH/NINDS, Dr. Hotz (site PI)
  • The neurocritical care outcome registry- Drs. O'Phelan and Alkhachroum (study PI). 
  • Near-infrared light to noninvasively measure critical closing pressure of cerebral circulation: comparison of calculated measurement to true critical closing pressure during ventricular fibrillation – Dr. Mahanna-Gabrielli (study PI).  
  • Melatonin receptor 1B SNP and cognitive disorders in Latinos - Dr. Mahanna-Gabrielli (study PI).  
 

Selected Publications

  • What is the Role of Hyperosmolar Therapy in Hemispheric Stroke Patients? Mohney N, Alkhatib O, Koch S, O'Phelan K, Merenda A., Neurocrit Care. 2019 Jul 24. doi: 10.1007/s12028-019-00782-9. [Epub ahead of print] Review. PMID: 31342452
  • Emergency Neurological Life Support: Third Edition, Updates in the Approach to Early Management of a Neurological Emergency. O'Phelan KH, Miller CM., Neurocrit Care. 2017 Sep;27(Suppl 1):1-3. doi: 10.1007/s12028-017-0448-x. PMID:28913811
  • And the Beat Goes on…Heart Rate Variability After Spontaneous Intracranial Hemorrhage. O'Phelan K., Neurocrit Care. 2019 Apr;30(2):251-252. doi: 10.1007/s12028-019-00696-6. PMID: 30847726
  • Therapeutic temperature modulation is associated with pulmonary complications in patients with severe traumatic brain injury. O'Phelan KH, Merenda A, Denny KG, Zaila KE, Gonzalez C., World J Crit Care Med. 2015 Nov 4;4(4):296-301. doi: 10.5492/wjccm.v4.i4.296. eCollection 2015 Nov 4. PMID: 26557480
  • Understanding the Functional Neuroanatomical Basis of Meditation for Improving Patient Wellness and Outcomes. Dangayach NS, O'Phelan KH., World Neurosurg. 2018 Apr;112:294-296. doi: 10.1016/j.wneu.2018.02.063. Epub 2018 Feb 16. No abstract available. PMID:29458186
  • The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol. Vespa PM, Shrestha V, Abend N, Agoston D, Au A, Bell MJ, Bleck TP, Blanco MB, Claassen J, Diaz-Arrastia R, Duncan D, Ellingson B, Foreman B, Gilmore EJ, Hirsch L, Hunn M, Kamnaksh A, McArthur D, Morokoff A, O'Brien T, O'Phelan K, Robertson CL, Rosenthal E, Staba R, Toga A, Willyerd FA, Zimmermann L, Yam E, Martinez S, Real C, Engel J Jr. Neurobiol Dis. 2019 Mar;123:110-114. doi: 10.1016/j.nbd.2018.07.025. Epub 2018 Jul 23. Review. PMID:30048805
  • Common Patterns of Regional Brain Injury Detectable by Diffusion Tensor Imaging in Otherwise Normal-Appearing White Matter in Patients with Early Moderate to Severe Traumatic Brain Injury. O'Phelan KH, Otoshi CK, Ernst T, Chang L., J Neurotrauma. 2018 Mar 1;35(5):739-749. doi: 10.1089/neu.2016.4944. Epub 2018 Feb 9. PMID: 29228858
  • Impact of methamphetamine on regional metabolism and cerebral blood flow after traumatic brain injury. O'Phelan K, Ernst T, Park D, Stenger A, Denny K, Green D, Chang C, Chang L., Neurocrit Care. 2013 Oct;19(2):183-91. doi: 10.1007/s12028-013-9871-9. PMID: 23836426
  • Predictors of clinical failure of decompressive hemicraniectomy for malignant hemispheric infarction. Merenda A, Perez-Barcena J, Frontera G, Benveniste RJ., J Neurol Sci. 2015 Aug 15;355(1-2):54-8. doi: 10.1016/j.jns.2015.05.012. Epub 2015 May 17. PMID:26071890
  • Cracking the Role of Cocaine in Stroke. Merenda A, Muir KW, Koch S. Stroke. 2016 Apr;47(4):909-10. doi: 10.1161/STROKEAHA.116.012681. Epub 2016 Mar 10. No abstract available. PMID:26965852
  • Craniectomy for acute ischemic stroke: how to apply the data to the bedside. Merenda A, DeGeorgia M., Curr Opin Neurol. 2010 Feb;23(1):53-8. doi: 10.1097/WCO.0b013e328334bdf4. Review. PMID:19949331
  • Successful Use of Extracorporeal Membrane Oxygenation for Respiratory Failure After Cranial Surgery. Mohney N, Morcos J, Merenda A., World Neurosurg. 2018 Dec;120:426-429. doi: 10.1016/j.wneu.2018.09.087. Epub 2018 Sep 24. PMID:30261384
  • Validation of brain extracellular glycerol as an indicator of cellular membrane damage due to free radical activity after traumatic brain injury. Merenda A, Gugliotta M, Holloway R, Levasseur JE, Alessandri B, Sun D, Bullock MR. J Neurotrauma. 2008 May;25(5):527-37. doi: 10.1089/neu.2007.0359. PMID:18363507
  • EEG to detect early recovery of consciousness in amantadine treated acute brain injury patients. Alkhachroum A, Eliseyev A, Der-Nigoghossian C, Rubinos C, Kromm J, Mathews E, Bauerschmidt A, Doyle K, Velazquez A, Egbebike J, Calderon A, Roh DJ, Park S, Agarwal S, Connolly ES, Claassen J. Journal of Neurology, Neurosurgery, and psychiatry. 2020, April 1st. PMID: 32241920.
  • Harnessing big data in neurocritical care in the era of precision medicine. Alkhachroum A, Terilli K, Megjhani M, Park S. Curr Treatment Options in Neurology. 2020.
  • Hyperemia in subarachnoid hemorrhage patients is associated with an increased risk of seizures. Alkhachroum A, Megjhani M, Terilli K, Rubinos C, Ford J, Wallace BK, Roh DJ, Agarwal S, Connolly ES, Boehme AK, Claassen J, Park S. Journal of Cerebral Blood Flow & Metabolism. 2019 Jul 11:0271678X19863028. PMID: 31296131.
  • Rates and Trends of Endotracheal Intubation in Patients with Status Epilepticus. Alkhachroum AM, Rubinos C, Chatterjee A, Chen M, Martin A, Claassen J, Murthy SB, Merkler AE. The Neurohospitalist. 2019 Feb 21:1941874419830496. PMID: 31534607.
  • Risk of seizures and status epilepticus in older patients with liver disease. Alkhachroum AM, Rubinos C, Kummer BR, Parikh NS, Chen M, Chatterjee A, Reynolds A, Merkler AE, Claassen J, Kamel H. Epilepsia. 2018 Jun 6. PMID: 29873808.
  • Generalized periodic discharges with and without triphasic morphology. Alkhachroum AM, Al-Abri H, Sachdeva A, Maturu S, Waldron J, Wang H, Rizvi M, Vaca GF, Lüders HO. Journal of Clinical Neurophysiology. 2018 Mar 1;35(2):144-50. PMID: 29215453.
  • Common neurologic emergencies for nonneurologists: when minutes count. Kottapally M, Josephson SA. Cleveland Clinic journal of medicine. 2016 Feb;83(2):117.
  • Paroxysmal Sympathetic Hyperactivity with Dystonia Following Non-traumatic Bilateral Thalamic and Cerebellar Hemorrhage. Di Luca DG, Mohney NJ, Kottapally M. Neurocritical care. 2019 Jun 15;30(3):688-9.
  • Frailty is associated with postoperative delirium but not postoperative cognitive decline in older non-cardiac surgery patients. Mahanna-Gabrielli E, Zhang K, Sieber F, Hung Mo Lin, Xiaoyu Liu, Margaret Sewell, Deiner S, Boockvar, K. Anesthesia & Analgesia 2020; 130(6):1516-23.
  • State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018. Mahanna-Gabrielli E, Schenning KJ, Eriksson LI, Browndyke JN, Wright CB, Evered L, Scott DA, Wang NY, Brown IV CH, Oh E, Purdon P. British journal of anaesthesia. 2019; 123: 23(4):464-78.
  • Defining a Taxonomy of Intracranial Hypertension. Journal of Neurosurgical Anesthesiology. Kofke WA, Rajagopalan S, Ayubcha D, Balue R, Cruz-Navarro J, Manatpon P, Mahanna-Gabrielli E. 2020; 32(2):120-131. doi: 10.1097/ANA.0000000000000609
  • Continuous non-invasive optical monitoring of cerebral blood flow and oxidative metabolism after acute brain injury. Journal of Cerebral Blood Flow & Metabolism. Baker WB, Balu R, He L, Kavuri VC, Busch DR, Amendolia O, Quattrone F, Frangos S, Maloney-Wilensky E, Abramson K, Mahanna-Gabrielli E. Yodh AG, Kofke WA. 2019; 39(8):1469-1485.doi: 10.1097/ANA.0000000000000609.
  • Does the melatonin receptor 1B gene polymorphism have a role in postoperative delirium? Mahanna-Gabrielli E, Miano TA, Augoustides JG, Kim C, Bavaria JE, Kofke WA. PloS one. 2018 Nov 27;13(11):e0207941.
  • Long-Term Outcomes for Different Forms of Stress Cardiomyopathy After Surgical Treatment for Subarachnoid Hemorrhage. Bihorac A, Ozrazgat-Baslanti T, Mahanna E, Malik S, White P, Sorensen M, Fahy BG, Petersen JW. Anesthesia & Analgesia. 2016 May 1;122(5):1594-602.