Course Descriptions

The Clinical Applications of Genomic Medicine series provides genomic medicine case studies and systems-based learning. Topics covered in the Fall include cardiovascular, respiratory, renal/urinary, gastrointestinal/nutritional systems.

This course introduces foundational concepts in research ethics in preparation for conducting the genomic medicine practicum. Online Human Subjects Research and Responsible Conduct of Research training through the CITI Program website will be supplemented with three hours of in-person discussion sessions.

This course provides introductory background for understanding genomics and genomic techniques, including genomic medicine case studies and systems-based learning. Initial topics include basic concepts of genomic medicine, genomic techniques involved in clinical applications, integration of genomic medicine into the clinical setting, importance of translational research, patient and physician benefits, and transitioning the medical curriculum into case studies. This course is focused on complex genetic disorders, and use of web-based tools in clinical work.

This course prepares students to evaluate the clinical utility of a genetic test and apply that information in a clinical setting. Illustrations of these concepts are drawn from the systems-based curriculum spanning December (ophthalmology and dermatology) and spring (rheumatology, infection and immunity, hematology and oncology, diabetes and metabolism, and endocrinology and reproductive medicine). The class meets for two hours each week for literature-based discussion sessions and case-based learning.

Students rotate in the molecular genetics and biochemical genetics diagnostic laboratories, gaining experience with genomic testing in a clinical setting, and interpretation and communication of results.

This course helps students gain a working knowledge of computational methods used in primary and secondary analysis of genomic technologies and apply these to a clinical setting. It prepares students to perform practical data analysis in the GNM 631 course offered in spring.

This course introduces the scientific, socio-ethical, and policy issues arising in genomic medicine. It helps students improve critical thinking and provides the tools to evaluate the wide range of challenges genomic medicine brings to individuals and societies. The course covers a broad spectrum of topics –from the history of eugenics to genetic testing and screening through the life cycle (e.g., pre-implantation and pre-natal testing, newborn, population and carrier screening, and direct-to-consumer genetic testing), bioethical issues (e.g., informed consent, privacy, and confidentiality), policy issues (e.g., professional duties, patents, and discrimination), and societal issues (e.g., health disparities).

The purpose of this segment is to provide the research and clinical application aspects of training. It can be initiated at any point after admission to the MSGM Program, resulting in six credits earned in the spring of year four. Students summarize all components (case reports, mentored research project, genomic medicine education) in a portfolio of work and present it at the end of the capstone.