Contact
Zane Zeier, Ph.D.
Associate Professor, Department of Psychiatry & Behavioral SciencesOur studies focus on genetic and epigenetic approaches used in basic and translational research. Recently, we’ve focused our investigations on epigenetic mechanisms that underlie neurodegenerative and psychiatric diseases.
In one ongoing study, we’re using adeno-associated virus (AAV) vectors and CRISPR gene editing to excise the C9ORF72 repeat expansion mutation in iPSC and murine models of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Another project, funded by the Florida Center for Brain Tumor Research, uses a new glioblastoma (GBM) model system in which iPSC-derived brain organoids are co-cultured with patient-derived GBM cells to model proliferation and invasion. We’re using a high-content, image-based assay with GBM-organoids in our drug development efforts for GBM.