Contact
Zane Zeier, Ph.D.
Associate Professor, Department of Psychiatry & Behavioral SciencesResearch Focus
Our research focuses on neurological disease and its underlying causes to develop promising new therapies. We create induced pluripotent stem cells (iPSCs) — which allow us to study human neurons — to model neurodevelopmental and neurodegenerative diseases using 2D neuronal cultures and 3D cerebral brain organoids. This enables us to investigate how specific mutations lead to these diseases.
As a member of the Center for Therapeutic Innovation and Sylvester Comprehensive Cancer Center, our team has performed various compound screening campaigns using iPSC neurons and developed protocols for mass producing brain organoids to facilitate drug discovery projects. Our genome-wide transcriptomic and epigenomic profiling approaches are used to help further basic and clinical research.