Primary Appointment of Biochemistry and Molecular Biology
Member of the Sylvester Comprehensive Cancer Center
Biography
The laboratory studies mechanisms involved in the cellular adaptation to the adverse environmental conditions commonly found within the tumor microenvironment (hypoxia and extracellular acidosis). These extracellular stimuli alter fundamental cellular pathways by 1) activating an alternate translation apparatus that synthesizes proteins only in the absence of oxygen and 2) inducing a new class of long noncoding RNAs that regulate protein function. Ongoing projects blend basic and translational scientific research from the identification of novel stress-induced long noncoding RNA to discovery of drug as small molecular inhibitors for these essential tumor biology pathways.
Education & Training
Education
1994: McGill University, Montreal, Canada
PhD
Research Interests
Our laboratory works on stress-induced low complexity noncoding RNA, phase transition and physiological amyloidogenesis in the context of cancer and neurological disorders.
Publications
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