Her research interests lie in understanding the effects of inherited genetic mutations on the fallopian tube and breast epithelia and their involvement in high-grade serous and triple-negative breast cancer development. She studies homologous recombination deficiency (HRD), DNA damage repair response, the enzymes and pathways responsible for sensing in the context of women’s cancers. Specifically, in the laboratory Dr. George, studies fallopian tube epithelia from women deemed to be at a high-risk for developing breast and/or ovarian cancer and breast and ovarian tumors from women with a germline mutation BRCA mutation carriers. Her work with others has found that the menstrual cycle (hormones), inflammation, parity and obesity, all influence the development of ovarian cancer.
