Nagaraj Nagathihalli, Ph.D.

Roles

• Biography

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  Dr. Nagaraj Nagathihalli, Ph.D., is a cancer biologist at the Sylvester Comprehensive Cancer Center, an Associate Professor in the Department of Surgery, and a graduate faculty in the Cancer Biology Program at the University of Miami School of Medicine. Dr. Nagathihalli obtained his postgraduate training in biochemistry from the University Of Mysore, India, and his Ph.D. from the Defence Research Laboratory and the University of Mysore, India, with a DRDO National Research Fellowship. Until 2015, he was a Postdoctoral Fellow, Instructor, and Research Assistant Professor at the Vanderbilt Cancer Center at Vanderbilt University, USA. He has been the recipient of the Ed Nelson Research Award, Young Investigator Award from ISGO, American Pancreatic Association, ECOG, Scholarships from the American Institute for Cancer Research, CAPER, and American Association for Cancer Research (AACR), Stanley Glaser Research Award from the University of Miami, Sylvester Faculty Travel Award and Florida State's James and Esther King Biomedical Research Award. Dr. Nagathihalli served as Ad Hoc Grant Reviewer for NIH and DOD. Dr. Nagathihalli's laboratory investigates the dynamics of pancreatic cancer initiation, progression, response to therapy, and the emergence of resistance.

• Education & Training

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  Education

  2002: Defense Research Laboratory, DRDO

  PhD, Enzymology and Protein Biochemistry

  1996: University of Mysore

  MS, Biochemistry

  1994: Yuvaraja’s College, University of Mysore

  BS, Chemistry, Botany, Zoology

  Post Graduate Training

  2011: Vanderbilt University

  Post-Doctoral Fellowship, Pancreatic Cancer Models, Cancer Signaling and Drug Resistance

  2007: University of Louisville

  Post-Doctoral Fellowship, Cancer Biology

• Honors & Awards

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• Teaching Interests

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  Pancreatic Cancer Biology, Cell-Intrinsic Mechanisms, Tumor Immune Microenvironment, Targeted Therapy.

• Research Interests

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  Dr. Nagathihalli's research laboratory has a long-standing interest in the signaling pathways controlling tumorigenesis and therapeutic resistance with a special focus on the interface with risk factors in pancreatic cancer. Specifically, he is interested to understand how specific risk factors (tobacco smoking, alcohol) and mutations (Kras, p53, Smad4) influence the initiation, progression, and maintenance of pancreatic cancer by regulating signaling and therapy resistance using a multi-faceted approach that includes the application of gene array analyses, kinome profiling, chemical and genetic screenings, and state-of-the-art model systems [genetically engineered mouse models, organoids, patient-derived cell lines and xenografts]. His laboratory has regularly made impactful contributions to the role of CREB, STAT3, ERK, EGFR, and Src in cell signaling. Using a multifaceted approach of CRISPR CAS9-based genome editing and pancreas-specific knock-out mouse models, their laboratory works to understand the biology of tumor cell-intrinsic CREB in shaping the tumor immune landscape of this malignancy.

• Publications

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• Professional Activities

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