Active roles of glial ion channels, transporters, and neuromodulators in synaptic signalingMolecular mechanisms by which glia regulate neuronal excitability and behaviorContributions of glial membrane proteins to nervous system dysfunction and agingGlia are the most abundant cell type in the nervous system. Once considered primarily supportive, glial cells are now recognized as active participants in synaptic signaling, responding to and modulating neuronal activity. Central to these functions are ions and signaling molecules that are released from glia or transported into them. The movement of these molecules across the plasma membrane is mediated by ion channels and transporters.
Despite their importance, our understanding of how these membrane proteins shape glial function—and, in turn, synaptic activity and animal behavior—remains incomplete. In many cases, the molecular identities of the relevant channels and transporters are still unknown. Our RNA-sequencing analyses have identified more than 30 glia-enriched membrane channels and transporters with potential roles in glia–neuron communication. Using complementary molecular, genetic, imaging, and electrophysiological approaches, we are defining how these proteins contribute to glial physiology, neuronal function, and behavior. We have also recently begun to investigate how glial ion channels and transporters influence nervous system aging.
