Proliferative cells, such as cancer cells and activated T cells, constantly rewire their metabolism to meet their evolving demands. In our laboratory, we use liquid chromatography-mass spectrometry (LC-MS) and bioinformatics tools to detect aberrant metabolites and uncover novel metabolite-protein interactions that drive cellular physiology and growth. By elucidating the biochemical mechanisms of metabolic adaptation at the cellular level, we aim to translate our discoveries into innovative therapeutic strategies.