Roles
Research Instructor
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Biography
My long-term research interest is to elucidate key molecular mechanisms that are activated in the kidney as a pathophysiological response to disease. My academic training and experiences have allowed me to develop an excellent background in multiple biological disciplines including medical sciences, biochemistry, cell and molecular biology and genetics. I have studied podocyte biology in several glomerular diseases, primarily diabetic nephropathy and nephrotic syndrome. During my masters at Yonsei University, I investigated the mechanism of podocyte injury under diabetic conditions. I characterized several podocyte protein expression patterns characteristic to diabetic nephropathy in an experimental rat model. During my doctoral dissertation under Drs. Mundel and Reiser’s mentorship at the University of Miami, Miller School of Medicine, I specifically focused on calpain, a cysteine protease, that induces podocyte foot process effacement by talin and synaptopodin cleavage, suggesting that nephrotic syndrome is an enzymatic disease. I joined Dr. Fornoni’s laboratory at the University of Miami, Miller School of Medicine as a post-doctoral trainee, and I have been expanding my knowledge on the role of lipid-pathways in podocyte biology and extracellular matrix biology in the healthy and diseased kidney. My research was focused on how the activation of DDR1 in podocytes lipotoxicity linking to abnormal glomerular basement membrane (GBM) of Alport syndrome. However, the downstream mechanism by which lipid accumulation contributes to podocyte lipotoxicity in AS remains to be elucidated and is a major focus of my study. -
Honors & Awards
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Research Interests
My current research interests are; 1) How Plin5 deficiency affects on podocyte injury in the progression of Alport Syndrome.
2) How the podocytes response to different glomerular basement membrane stiffness in the progression of Alport Syndrome. -
Publications
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