Roles
Research Assistant Professor
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Education & Training
Education
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Honors & Awards
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Research Interests
My research focuses on evaluating the biological importance of the innate immune sensor, referred to as Stimulator of IFN genes (STING). STING is one of the innate immunity sensors activated by cytosolic DNA, such as cyclic dinucleotides (CDNs) secreted by intracellular bacteria or generated by a cellular cGAMP synthase (cGAS). While transient STING function has found to be essential for protection of the host against viral infection, chronic STING activity by self-DNA leaked from the nucleus has been implicated in causing lethal autoinflammatory diseases such as severe systemic lupus erythematosus (SLE) and STING-associated vasculopathy with onset in infancy (SAVI). Our research has been proving that STING dependent innate immune signaling could contribute towards auto-inflammatory disease, inflammation-driven cancer such as skin cancer and colitis-associated cancer as well as host defense mechanisms. We have been developing new drug candidates targeting STING dependent innate immune signaling pathway, which holds considerable promise for the therapeutic treatment of cancer and inflammatory diseases as well. My research goal is to develop translational applications in fundamental research into medical practice and ultimately develop new therapeutics that will help manage these prevalent inflammatory diseases and cancer. -
Publications
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Copyrights & Patents