Roles
Professor and Founding Chair (2008-2013), Dr. John T. Macdonald Foundation Department of Human Genetics
Professor of Neurology
Director, Center for Genomic Education & Outreach, John P. Hussman Institute for Human Genomics
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Biography
Jeffery M. Vance, M.D., Ph.D. is a Professor in the Dr. John T. Macdonald Foundation Department Human Genetics (founding Chairman, 2008-2012) and a Professor of Neurology at the University of Miami, Miller School of Medicine. He is boarded by both the American Board of Psychiatry and Neurology and the American College of Medical Genetics and is an elected member of the Academy of Science, Engineering and Medicine of Florida (ASEMFL). His research has focused on the application of clinical, molecular, and mathematical genetic techniques to identify genes leading to human disease. He has collaborated on research in many different clinical specialties, but primary focus is on neurodegenerative disorders (Parkinson and Alzheimer disease) and Charcot-Marie-Tooth disease, as well as Autism. His research focuses on both functional genomic studies as well as clinical and genetic studies of neurodegenerative disease. His current laboratory research focuses on identifying the protective variant(s) that lowers the risk for Alzheimer disease (AD) in African American ApoE4 carriers relative to European carriers of the ApoE4 allele to develop therapeutic protective mechanisms. In addition, his laboratory has NIH funding to work to identify the regulatory architecture of the African and Amerindian genomes, then apply this to genetic loci specific for African Americans and Hispanic Americans to identify the driving associated genes. As a member of the Alzheimer Disease Sequencing Project (ADSP), he is also involved in the ADSP-Follow-up studies (ADSP-FUS) seeking to increase diversity in Alzheimer disease research as an MPI of a NIA FUS funded grant and a U19 to increase participation in AD research for African, African-American and Hispanic individuals. As part of this work, he serves on several clinical adjudication committees to evaluate AD diagnoses for the ADSP consortium. He is a recipient of a prestigious Zenith Award from the Alzheimer's Association for his ApoE4 work. He is also capstone director of the Genomic Medicine Master degree program for medical students and the Principle investigator for the JJ Vance summer internship program at the HIHG. He receives funding from NIH (NIA, NINDS), The BrightFocus Foundation, the Alzheimer Association and the Hussman Foundation. -
Education & Training
Education
Post Graduate Training
Licensures and Certifications
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Honors & Awards
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Teaching Interests
Dr. Jeffery Vance is the capstone director of the Genomic Medicine Master degree program for medical students. -
Research Interests
Dr. Vance’s research has focused on the application of clinical, molecular, and mathematical genetic techniques to identify genes leading to human disease. He has collaborated on research in many different clinical specialties, but primary focus is on neurodegenerative disorders (Parkinson and Alzheimer disease) and Charcot-Marie-Tooth disease, as well as Autism. His current laboratory research focuses on identifying the protective variant(s) that lowers the risk for Alzheimer disease (AD) in African American ApoE4 carriers relative to European and Asian carriers of the ApoE4 allele, mapping the regulatory architecture for the African and Amerindian genomes, and as an MPI of grants focused on the inclusion of African, African-American and Hispanic individuals into research on Alzheimer disease. -
Publications
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Copyrights & Patents
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Professional Activities
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