Roles
- Professor
- Chief, Lymphoma Section
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Biography
Izidore Lossos, M.D., is a Professor of Clinical Medicine and Director of the Lymphoma Program at Sylvester Comprehensive Cancer Center, where he holds an endowed chair. He earned his medical degree from Hadassah School of Medicine at Hebrew University in Jerusalem and completed his residency and fellowship in hematology at Hadassah University Hospital, followed by a postdoctoral fellowship at Stanford University. Dr. Lossos’ research focuses on lymphoma pathogenesis, molecular prognostic markers, and novel therapies. He has authored more than 365 publications and has received multiple awards, including the Celgene Young Investigator Award (2007) and the Sylvester Outstanding Cancer Research Award (2012). He is a national and International expert in lymphoma. -
Education & Training
Education
Post Graduate Training
Licensures and Certifications
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Honors & Awards
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Research Interests
The laboratory is investigating pathogenesis of different subtypes of non-Hodgkin's lymphomas as well as novel therapeutic approaches. Specific interests are in: 1) Function of the HGAL gene in lymphoma dissemination and BCR signaling; 2) Role of LMO2 protein in pathogenesis of DLBCL; 3) Alterations in DNA repair mechanisms in lymphoma; 4) pathogenesis of orbital marginal zone lymphomas; 5) Function and targeting of PRMT5 protein in DLBCL. -
Publications
Disclaimer: Information presented in this section has been consolidated using AI and machine learning technologies. While every effort has been made to ensure accuracy, errors may occur. If you identify any inaccuracies, use this link to inform our data team. Your feedback is appreciated and helps us improve the quality of our content.Copyrights & Patents
Professional Activities
Articles & News
Antibody Shows Encouraging Results for Treating High-risk Follicular Lymphoma and Marginal Zone Lymphoma
Dean’s Faculty Awards: Celebrating Academic and Clinical Excellence
Lymphoma Experts Featured in WHO Book on Hematolymphoid Tumors
Disclaimer:
Information presented in this section has been consolidated using AI and machine learning technologies. While every effort has been made to ensure accuracy, errors may occur. If you identify any inaccuracies, use this link to inform our data team. Your feedback is appreciated and helps us improve the quality of our content.
Clinical Trials
Viewing 0 of 18 clinical trials.
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A Three-Arm Study of ME-401 Monotherapy in Subjects With Relapsed/Refractory CLL, SLL, or FL, of ME-401 in Combination With Rituximab in Subjects With Relapsed/Refractory CLL/SLL or B-cell NHL, and of ME-401 in Combination With Zanubrutinib in Subjects With Relapsed/Refractory CLL/SLL or B-cell NHL
- Principal Investigator: Izidore Lossos
- Study Phase: Phase 1
- Enrollment Status: Closed
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A Phase 2, Open-label, Study Evaluating Safety and Efficacy of the Loncastuximab in Relapsed/Refractory Marginal Zone Lymphoma
- Principal Investigator: Izidore Lossos
- Study Phase: Phase 2
- Enrollment Status: Open
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The purpose of this study is to assess the safety and tolerability of ABBV-319 in subjects with B-cell malignanciesThe purpose of this study is listed here:•To find a safe and tolerable dose and schedule of ABBV-319 in subjects with B-cell malignancies •To see how much ABBV-319 is in your blood at various times (these tests are called “Pharmacokinetics” or “PK”)•To determine whether or not ABBV-319 is effective in treating B-cell malignancies
- Principal Investigator: Izidore Lossos
- Study Phase: Phase I
- Enrollment Status: Closed
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This study will assess the efficacy and safety of mosunetuzumab in combination with polatuzumab vedotin (M+P) in participants with relapsed or refractory (R/R) diffuse-large B-cell lymphoma (DLBCL), high-grade B-cell lymphoma, transformed follicular lymphoma (trFL) and FL Grade 3B (FL3B) in comparison with a commonly used regimen in this participant population, rituximab, gemcitabine and oxaliplatin (R-GemOx).
- Principal Investigator: Izidore Lossos
- Study Phase: Phase III
- Enrollment Status: Closed
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A Phase 1 Dose Finding Study of Lutetium (177Lu)-Lilotomab Satetraxetan (Betalutin®) in Patients With Relapsed/Refractory, Diffuse Large B-cell Lymphoma, Not Eligible for Autologous Stem Cell Transplant
- Principal Investigator: Izidore Lossos
- Study Phase: Phase 1
- Enrollment Status: Closed
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A Phase I, Open-label, Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of GSK3326595 in Subjects With Solid Tumors and Non-Hodgkin's Lymphoma
- Principal Investigator: Izidore Lossos
- Study Phase: Phase 1
- Enrollment Status: Closed
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A Phase 2, Open-Label, 2-Cohort Study of INCB050465, a PI3Kδ Inhibitor, in Subjects With Relapsed or Refractory Marginal Zone Lymphoma With or Without Prior Exposure to a BTK Inhibitor (CITADEL-204)
- Principal Investigator: Izidore Lossos
- Study Phase: Phase 2
- Enrollment Status: Closed
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To evaluate the efficacy of glofitamab monotherapy compared with an investigators choice of BR or R-Len with respect to PFS
- Principal Investigator: Izidore Lossos
- Study Phase: Phase III
- Enrollment Status: Open
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A Phase Ib/II, Open-Label, Multicenter, Randomized, Controlled Study Investigating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With CHOP or CHP-Polatuzumab Vedotin in Patients With B-Cell Non-Hodgkin Lymphoma
- Principal Investigator: Izidore Lossos
- Study Phase: Phase 1/Phase 2
- Enrollment Status: Closed
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An Open-Label, Randomized, Multicenter, Phase Ib/II Trial Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With Polatuzumab Vedotin in Patients With B-Cell Non-Hodgkin Lymphoma
- Principal Investigator: Izidore Lossos
- Study Phase: Phase 1/Phase 2
- Enrollment Status: Not Accepting
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An Open-label, Phase 1b/2 Study of Acalabrutinib Alone or in Combination Therapy in Subjects With B-cell Non-Hodgkin Lymphoma
- Principal Investigator: Izidore Lossos
- Study Phase: Phase 1
- Enrollment Status: Not Accepting
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The purpose of this study is to test a new medication called mosunetuzumab to see if it can help people with EMZL. This study will include people who have not yet received any treatment for their cancer and whose cancer is in stage I-IV. This study will help doctors understand if mosunetuzumab improves outcomes in people with EMZL and if it is safe to use.
- Principal Investigator: Izidore Lossos
- Study Phase: Phase II
- Enrollment Status: Open
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ILyAD (Indolent Lymphoma And Vitamin D) A Phase III Double Blind, Randomized Trial to Evaluate the Supplemental Effect of Vitamin D on Progression-free Survival in Patients With Low Tumor-burden Indolent Non-Hodgkin Lymphoma Treated With Rituximab
- Principal Investigator: Izidore Lossos
- Study Phase: Phase 3
- Enrollment Status: Closed
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To determine the complete response (CR) rate after cycle 12 of therapy in patients with untreated MZL. We have previously reported that achievement of CR is one of the best predictors for progression-free survival (PFS) and overall survival (OS) in patients with MZL.
- Principal Investigator: Izidore Lossos
- Study Phase: Phase II
- Enrollment Status: Open
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Long-term Follow-up and/or Continued Thalidomide (THALOMID®) Maintenance Therapy for Patients Enrolled on Clinical Trial 20030165
- Principal Investigator: Izidore Lossos
- Study Phase: Phase 2
- Enrollment Status: Closed
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This study and protocol will address 3 aims:1)Establishment of lymphoma tissue bank. 2)Establishment of lymphoma clinical data-base.3)Molecular analysis of DNA, RNA and proteins in the lymphoma cells.
- Principal Investigator: Izidore Lossos
- Study Phase: N/A
- Enrollment Status: Open
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Lymphoma Epidemiology of Outcomes Cohort Years 6-10
- Principal Investigator: Izidore Lossos
- Study Phase: N/A
- Enrollment Status: Open
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Phase II Study of Rituximab in Combination With Methotrexate, Doxorubicin, Cyclophosphamide, Leucovorin, Vincristine, Ifosfamide, Etoposide, Cytarabine and Mesna (R-MACLO/VAM) in Patients With Previously Untreated Mantle Cell Lymphoma
- Principal Investigator: Izidore Lossos
- Study Phase: Phase 2
- Enrollment Status: Closed
