Roles
Research Assistant Professor of Surgery
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Biography
I am currently a Research Assistant Professor at the University of Miami, with a long-term research goal of elucidating the molecular mechanisms underlying the tumorigenesis and therapeutic resistance of human esophageal adenocarcinoma.
My research focuses on the roles of reactive oxygen species (ROS) signaling and the redox-regulating protein APE1 in driving cancer progression and shaping the tumor microenvironment. By integrating cellular, molecular, and translational approaches, my work aims to identify novel diagnostic and therapeutic strategies targeting redox imbalance and chemo-resistant signaling transduction in esophageal cancer.
With over 50 peer-reviewed publications in leading journals such as Gut, Gastroenterology, Cancer Research, Clinical Cancer Research, and Redox Biology, my research contributions span cancer signaling, oxidative stress, and DNA damage response in Barrett’s carcinogenesis.
Ultimately, my goal is to translate these mechanistic insights into improved treatment options for patients with esophageal and related cancers. -
Education & Training
Education
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Research Interests
My research focuses on elucidating the molecular mechanisms driving the development and chemoresistance of esophageal adenocarcinoma. Specifically, I investigate how oxidative stress and redox imbalance, mediated by reactive oxygen species (ROS), influence DNA damage responses, tumor progression, and therapeutic outcomes.
A central focus of my work is the multifunctional protein APE1 (apurinic/apyrimidinic endonuclease 1), a key regulator of DNA repair and redox signaling. I aim to define how APE1 dysregulation and aberrant ROS signaling promote chemoresistance and tumor adaptation. Using complementary in vitro and in vivo models, I dissect the interplay between APE1-mediated redox control, oxidative DNA damage, and treatment response.
To achieve this, I employ a combination of in vitro and in vivo models to dissect the molecular interplay between APE1-mediated redox regulation, oxidative DNA damage, and therapeutic response. The ultimate goal of my research is to identify novel redox-based therapeutic targets to overcome chemoresistance, particularly through combination strategies integrating DNA-damaging agents and immunotherapies, to improve treatment outcomes for patients with esophageal adenocarcinoma. -
Publications
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