Associate Professor of Microbiology and Immunology
Director Program in Biomedical Sciences (PiBS)
Education & Training
1997: Northwestern University, Evanston, IL USA
PhD, Microbial Metal Ion Resistance
1988: Rollins College, Winter Park, FL USA
Post Graduate Training
2001: Emory University, Atlanta, GA USA
Post-Doctoral Fellowship, Bacterial Pathogenesis
1995: National Science Foundation, McMurdo Station, Antartica
Other, Biological Adaptations of Antarctic Marine Organisms
1988: Argonne National Laboratory, Argonne, IL USA
Other, Biological Effects of Ionizing Radiation
The molecular and cellular biology of the bactericidal pore-forming protein Perforin-2 (MPEG1) is a major area of emphasis within the Munson laboratory. Concurrently we are using multidisciplinary approaches to discover and characterize bacterial effectors that subvert or inhibit the bactericidal activity of Perforin-2 with a particular emphasis on enteric and multidrug resistant pathogens. We are also developing heavy chain only antibodies to advance our Perforin-2 studies. Unlike conventional immunoglobulins this class of antibodies –often referred to as VHHs, llama-bodies, or nanobodies– lack light chains. Because the paratope resides within a single domain, nanobodies are easily engineered and can be expressed in a variety of species including bacteria. Other areas of research include a novel protein modification and secretion system of enterotoxigenic E. coli (ETEC) and transcriptional regulators of bacterial virulence.
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