Roles
Research Assistant Professor | Computational Biologist
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Biography
Dr. Fulvio D’Angelo is a Research Assistant Professor at the Sylvester Comprehensive Cancer Center, University of Miami, specializing in cancer genetics with a focus on the molecular heterogeneity and evolution of nervous system tumors.
Dr. D’Angelo earned his PhD in Genetics in 2011 from the University of Naples Federico II, where he studied molecular cloning and phenotyping in genetically engineered mouse models. Early in his training, he gained hands-on experience in experimental biology, but as a scientist living with a neuromuscular condition, he faced increasing challenges performing physically demanding benchwork. This led to a pivotal shift toward computational biology. Through formal training in bioinformatics and high-throughput genomic analysis, he developed the expertise to explore complex biological questions using large-scale datasets—an approach that continues to define his research.
During his postdoctoral work in the labs of Dr. Antonio Iavarone and Dr. Anna Lasorella at Columbia University in the city of New York, Dr. D’Angelo focused on the genomic landscape of NF-1 glioma. His study, published in Nature Medicine (D’Angelo et al., 2019), presented the first comprehensive map of the genetic and epigenetic alterations driving these tumors, representing a foundational advancement in both NF-1 research and glioma biology. His current work builds on this foundation, applying single-cell genomics and integrative analyses to dissect tumor heterogeneity, immune interactions, and therapy resistance in sporadic and syndromic glioma.
As an early-stage professor, Dr. D’Angelo brings a unique combination of molecular and computational expertise to his research. This dual skill set allows him to approach cancer biology from multiple angles.
Dr. D’Angelo’s experience as a disabled researcher has shaped his scientific perspective and approach. Navigating the dual challenges of a physically limiting condition and a demanding research environment has fostered resilience, adaptability, and a focused determination to contribute meaningfully to the field of cancer research. -
Education & Training
Education
Post Graduate Training
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Research Interests
Dr. Fulvio D'Angelo's research investigates the genetic and epigenetic drivers of glioma, including those associated with Neurofibromatosis type 1 (NF-1), a genetic disorder that predisposes individuals to tumors of the nervous system. By integrating laboratory-based methods with computational biology, Dr. D’Angelo aims to uncover how glioma evolve, interact with the immune microenvironment, and resist therapy—ultimately informing new therapeutic strategies for brain cancer. His most recent work on glioblastoma investigates tumor heterogeneity and genetic clonal evolution, providing insight into the functional mechanisms of treatment resistance and informing future therapeutic strategies. -
Publications
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