Roles
Associate Professor of Clinical Anesthesiology
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Biography
1. I have over twenty-five years of experience as a clinician scientist in the areas of pain, neuroscience, inflammation, and perioperative monitoring. My previous research and clinical experiences have prepared me to address the medical sequelae related to extreme heat, which include respiratory, cardiovascular and neurological complications. In the past, I received NIH funding (1R03DA031410-10) to study intracellular calcium regulation, which can be involved in the signaling cascade of hyperthermic heat stroke processes. As a perioperative physician, I have studied the role of respiratory, cardiovascular, and central nervous system (CNS) monitoring to prevent adverse outcomes in critically ill patients. These monitoring modalities will be applicable to patients who encounter the effects of severe heat stress. By gathering knowledge of the health effects related to environmental stressors and bioaerosols, I will be collaborating with the Florida Clinicians for Climate Action (FCCA) to translate and disseminate this important information to emergency workers and teams of clinicians involved with primary care, emergency care and critical care.
2. My studies at the University of South Florida focused on clinical strategies to improve perioperative analgesia. In murine models, I studied the effects of anesthetics on blunting spinal cord wind up and cytokine inflammation after surgical or noxious stimulation. In rabbit models, I studied the uptake of drug molecules in the epidural space in both normal and diseased animals, which provided further insights into the mechanisms of epidural analgesia.
3. My research in pain at the University of Miami focused on genetic and inflammatory mechanisms in collaboration with neuroscientists at the Miami Project to Cure Paralysis, I utilized transgenic mice mouse model to assess the role of NF-Kappa B inhibition in alleviating pain after peripheral nerve inflammation and injury. I received NIH funding to study the how the carbonic anhydrase 8 gene is involved in nociception. We found that this gene is important in treating inflammatory pain and calcium regulation.
4. I investigated strategic approaches to treat spinal cord injury and ischemia in rodent and rabbits, which includes stem cell therapy, corticosteroids and intercellular adhesion molecules. -
Education & Training
Education
Licensures and Certifications
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Honors & Awards
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Research Interests
Research Interests:
1. Neural injury processes in relation to the inflammatory pathways (cytokine/ICAM-1/NF-kappa B) and cell transplantation.
2. Spinal cord uptake of epidural agents in spinal cord diseases processes such as experimental allergic encephalomyelitis.
3. Postoperative pain mechanisms involving processing of spinal cord nociceptive input in relation to preemptive analgesia and regional anesthesia.
4. Anesthetic monitoring in relation to oxygenation, hypoventilation, and bispectral index.
5. Genetic mechanisms of peripheral nerve injury and neuropathic pain in relation to intracellular calcium release.
6. Postoperative Vision Loss (POVL) Study Group.
7. Health disparities research in relation to ethnicity, climate change and socioeconomic barriers. Serving on the Miami Dade County Asian Advisory Board and Florida Clinicians for Climate Action.
8. Metabolic and calcium related responses to extreme heat and climate change. -
Publications
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Professional Activities
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