Roles
Assistant Professor of Clinical
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Biography
Dr. Alexandra Dreyfuss is a radiation oncologist who specializes in the treatment of breast cancer and hematologic malignancies. She provides comprehensive care for individuals with breast cancer, lymphoma, multiple myeloma, and leukemia, and treats select inflammatory and degenerative benign conditions.
Dr. Dreyfuss received her bachelor’s degree in science and engineering and her medical degree from the University of Pennsylvania. She also earned a Master of Science in Translational Research at the University of Pennsylvania, dedicating two years to advanced training in clinical investigation and translational science as an NIH TL1 grant recipient. She completed her internship and radiation oncology residency at Memorial Sloan Kettering Cancer Center (MSKCC), where she developed a strong focus on hematologic malignancies and breast cancer and completed a clinical research fellowship in hematologic radiation oncology. She also served as Chief Resident during her final year.
Throughout her training, Dr. Dreyfuss cultivated a clinical and academic interest in modern radiation therapy techniques (proton therapy, intensity modulated radiation therapy, volumetric arc radiation therapy, total skin electron beam radiation), biomarker-driven treatment personalization, and the integration of radiation therapy with novel systemic and immune-based therapies. She has presented widely on these topics at national and international meetings. Her work reflects a commitment to advancing multidisciplinary care while bridging clinical practice with translational science to inform treatment personalization.
Dr. Dreyfuss was drawn to oncology by the opportunity to combine science with meaningful relationships with patients who are navigating some of the most challenging moments of their lives. She is particularly motivated by the rapid evolution of cancer therapeutics and by the role of radiation therapy as a precision modality that can be thoughtfully and selectively integrated with systemic treatments. She strongly believes in a multidisciplinary approach to cancer care and works closely with medical oncologists, surgeons, radiologists, pathologists, and other specialists to individualize treatment strategies. Central to her practice is shared decision-making, ensuring that recommendations are both evidence-based and aligned with what matters most to each patient. -
Education & Training
Education
Post Graduate Training
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Research Interests
Dr. Dreyfuss’s research is focused on advancing precision radiation therapy across breast cancer and hematologic malignancies through the integration of clinical outcomes, advanced imaging, biomarkers, and translational science. Her overarching goal is to define how radiation therapy can be optimally and selectively incorporated into modern, multimodal treatment paradigms that increasingly rely on targeted, immune-based, and cellular therapies. A central theme of her work is biologic- and imaging-driven personalization of radiation therapy, with an emphasis on refining patient selection, radiation timing, and dose strategies based on biologic risk rather than uniform, historic treatment approaches. She leads and contributes to a variety of clinical and translational research using large retrospective datasets and prospective clinical trial development.
In hematologic malignancies, Dr. Dreyfuss’s research is focused on lymphoma and plasma cell disorders. Her work examines patterns of progression and resistance in patients treated with contemporary systemic therapies, including immune checkpoint inhibitors, CAR T-cell therapy, and bispecific antibodies. She studies the role of consolidative, adaptive, and focal radiation in improving disease control and managing limited progression, particularly in the relapsed and refractory setting. Her research incorporates patient-level and lesion-level analyses using clinical, imaging, and molecular data to identify when radiation therapy can improve outcomes while limiting unnecessary toxicity. She is actively involved in collaborative research efforts in hematologic radiation oncology that contribute to evolving clinical practice and guideline development.
In breast cancer, Dr. Dreyfuss’s research interests include modern radiation techniques, treatment personalization, and de-escalation strategies aimed at preserving long-term quality of life without compromising disease control. Her work emphasizes careful integration of radiation therapy with systemic treatment advances and multidisciplinary care. She is particularly interested in evidence that supports refining radiation recommendations based on patient characteristics and disease biology.