Agenda

Welcoming Remarks

Nima Sharifi, M.D.

Session 1: Metabolic Interventions in Human Health and Disease

Interventional Cardiac Metabolic Pathophysiology

Zoltan Pierre Arany, M.D., Ph.D.

Ketogenic Fasting Interventions in Prostate Cancer

Laura Sena, M.D., Ph.D.

Fatty Acid Synthase Inhibition Clinical Studies in Prostate Cancer

Massimo Loda, M.D.

Metabolic Health and Prostate Cancer Survivorship

Alicia Morgans, M.D., M.P.H.

Session 2: Prostate Cancer Metabolism

Androgen Production, Uptake, and Conversion Enzymes in CRPC

Charles Ryan, M.D.

Alternative Androgen Synthesis Pathways in Prostate Cancer

Nima Sharifi, M.D.

Pyruvate Kinase is a Therapeutic Target in Prostate Cancer

Daniel Schmidt, M.D., Ph.D.

A Stress-Adaptive Lipid Kinase Axis Defines Metabolic Vulnerabilities in Neuroendocrine Prostate Cancer

Yuanyuan Qiao, Ph.D.

Session 3: Metabolic Mechanisms and Approaches

Targeting Metabolism in Prostate Cancer

Shaun Stauffer, Ph.D.

Dark GPCRs and Mitochondrial Transport

Daniel Isom, Ph.D.

Ketone-body Dependent Post Translational Modifications

Zhipeng Wang, Ph.D.

Closing Remarks

Nima Sharifi, M.D.

Session 1: Metabolism in Human Health and Disease

Welcoming remarks

Nima Sharifi, M.D.

Mitochondrial Dynamics and Cardiometabolic Disease

Dale Abel, M.D., Ph.D.

Insulin Regulation of Bile Acid Physiology

Rebecca Haeusler, Ph.D.

Metformin Intervention in STAMPEDE

Silke Gillessen, M.D.

Human Steroid Metabolism Phenotypes

Nima Sharifi, M.D.

Muscle Metabolic Alterations with Physical Activity and Disuse

Blake Rasmussen, Ph.D.

Session 2: Dietary Interventions to Combat Metabolic Dysfunction

Dietary Interventions and Nutrient Availability in Cancer Progression

Evan Lien, Ph.D.

Nutritional Strategies to Improve Metabolic Health and Potentially Longevity

Eric Ravussin, Ph.D.

A ketone shunt generates anti-obesity ketone metabolites

Maria Dolores Moya Garzon, Ph.D.

Session 3: Approaches for Studying Human Metabolism

Spatial Imaging of Metabolites Paired with Transcript and Peptide Imaging

Erin Seeley, Ph.D.

Toward Single Cell Resolution for Mass Spectrometry Metabolite Imaging

Jens Soltwisch, Ph.D.

Physiomimetic Microsystems for Studying Metabolism

Ashutosh Agarwal, Ph.D.

Welcoming Remarks

Nima Sharifi, University of Miami

Session 1: Normal Metabolism and the Diversity of Human Metabolic Phenotypes

Overarching Perspectives on Metabolism

Ralph DeBerardinis, Howard Hughes Medical Institute, UT Southwestern

Opportunities for Studying Diverse Populations in Miami

Brandon Mahal, University of Miami

Prostate Cancer and Genetic Ancestry in Jamaican Men

Chad Ritch, University of Miami

Session 2: What Happens When Metabolism Goes Awry?

Metabolic Adverse Effects of Hormonal Therapy

Alicia Morgans, Dana-Farber Cancer Institute, Harvard Medical School

Metabolic Stress in Men Training for the Special Forces

Harris Lieberman, Department of Defense

Effects of Stress and Hormonal Therapy on Steroid Metabolism

Nima Sharifi, University of Miami

Session 3: How Can We Favorably Modify Human Metabolism?

Time Restricted Eating as a Method to Optimize Metabolism

Satchidananda Panda, Salk Institute

Mechanistic Consequences of Amino Acid Deprivation on Translation

Alicia Darnell, Massachusetts Institute of Technology

Dietary Interventions with Cancer Therapy

Marcus Goncalves, Weill Cornell Medicine

Regulation of an Exercise-Inducible Appetite Suppressant

Shuke Xiao, Stanford University

Session 4: Approaches for the Study of Human Metabolism

Spatial Resolution of Carbohydrate Metabolism

Ramon Sun, University of Florida

Imaging Metabolic Dependence of the Myc Oncogene

Peter Kreuzaler, University of Cologne

Molecular Mapping at Cellular Resolution with Multimodal Imaging Mass Spectrometry

Jeffrey Spraggins, Vanderbilt University

Emerging Approaches for the Study of Metabolomics in Humans

Gary Patti, Washington University