July 10, 2024
Guest: Ashish H. Shah, M.D.
Listen Time: 29m 48s
In the previous episode of Inside U Miami Medicine, we explored promising advances in less-toxic treatments for brain cancer. Now, we continue our focus on glioblastoma, diving into promising research that uses viruses to weaken cancer cells.
Ashish Shah, M.D., a neurosurgeon and brain cancer researcher at Sylvester Comprehensive Cancer Center, part of the Miller School of Medicine, is weaponizing specific viruses to make brain cancer cells more susceptible to chemotherapy and radiation.
It’s a delicate process that involves delivering viral-based gene therapy directly into the tumor or tumor cavity to alter the fundamental genome of the cancer cells.
“Almost 50% of patients will succumb to [glioblastoma] in just over a year, despite our maximum surgical efforts, radiation and chemotherapy. That's quite devastating,” said Dr. Shah, assistant professor of neurological surgery and principal investigator of virology and immunotherapy at Sylvester’s Brain Tumor Institute. “So, I thought, ‘Are there ways that we can harness the immune system and use biologic therapies like viruses to really improve outcomes for these patients?’”
Tune in to the latest episode of the Inside U Miami Medicine podcast to hear more from Dr. Shah about his trailblazing work.
