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Do genetics increase Prostate Cancer Risk?

With guest Nima Sharifi, M.D.
Nima Sharifi, M.D.
Nima Sharifi, M.D.

September 25, 2024

Guest:Nima Sharifi, M.D.
Listen Time: 31m 13s

Nima Sharifi, M.D., scientific director of the Desai Sethi Urology Institute and a close collaborator with Sylvester Comprehensive Cancer Center, and his team are transforming how we understand and treat one of the most common and lethal cancers in men, prostate cancer.

While initial treatments offer hope, many patients find that their cancer returns with often fatal outcomes. But what if the key to stopping this deadly progression lies in our genes?

In this edition of “Inside U Miami Medicine,” Dr. Sharifi shares how genetic mutations, particularly in the HSD3B1 gene, influence the body’s response to prostate cancer treatment. His groundbreaking research revealed that a specific genetic variant enables tumors to bypass common treatments, effectively producing their own hormones to fuel cancer growth.

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Nima Sharifi

Nima Sharifi, M.D.

Professor
Publications
Biography: I am a prostate cancer medical oncologist and physician-scientist and the overall focus of my laboratory is to identify how steroid metabolism governs prostate cancer resistance to hormonal therapies, including development of castration-resistant prostate cancer (CRPC). Advanced prostate cancer responds initially to gonadal testosterone deprivation therapy but tumors eventually...
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