As the heart progresses toward heart failure, it produces high levels of a protein called Osteopontin, which is known to activate pathological remodeling of the heart. Lina Shehadeh, Ph.D., assistant professor of medicine in the Cardiovascular Division and the Interdisciplinary Stem Cell Institute, and a team of investigators decided to see if they could find a way to block Osteopontin signaling to prevent — or possibly even reverse — heart failure.
Working with a pharmacological molecule called an RNA aptamer, Shehadeh injected mice modeled for heart failure. Follow-up examinations revealed that the aptamer both prevented and reversed heart failure in the mice. The findings were significant because although aptamers have been used in cancer studies for many years, this study was the first exploring their potential role in treating heart failure. An article describing the research was published in the February issue of the Journal of Cardiovascular Research, with Shehadeh as senior author.
Already renowned for her work in hair and nail diseases, Antonella Tosti, M.D., a professor in the Department of Dermatology and Cutaneous Surgery at the University of Miami Miller School of Medicine, has been awarded the first Fredric Brandt Endowed Professorship.
Sylvester Comprehensive Cancer Center, part of UHealth – the University of Miami Health System, recently received four stars as part of the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey, conducted on behalf of the Centers for Medicare & Medicaid Services. Sylvester was the only hospital in Miami-Dade County to receive four stars.
Broken Heart Syndrome, or stress-induced cardiomyopathy, primarily affects middle-aged women who are going through emotional distress. Mauricio Cohen, M.D., an interventional cardiologist and researcher with UHealth – the University of Miami Health System, treats women with the condition, which can be triggered by any number of stressful events.
A brilliantly sunny South Florida Saturday warmed the already upbeat spirit of the Dolphins Cancer Challenge VII on February 11, as 4,000 participants and volunteers cycled, ran, walked or performed countless tasks to support the search for cancer cures at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine.
The Miller School of Medicine rose two positions in the national rankings of medical schools based on research grants received from the National Institutes of Health during the 2016 federal fiscal year. The NIH grants are vital for advancing research that leads to a greater understanding of a wide variety of diseases and public health issues.