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Professor of Neurological Surgery
Walter G. Ross Distinguished Chair in Developmental Neuroscience
BiographyFor many years Dr. Lemmon studied development of the nervous system, especially the role of cell adhesion molecules and extracellular matrix molecules. His early work on L1cam showed that it promotes axon growth (PNAS, 1987, Neuron, 1989) and his cloning of human L1cam allowed geneticists to discover its role in causing X-linked hydrocephalus. His lab did extensive work on L1cam signaling and recycling in the context of axon growth. Work in his lab by Diane Snow and in collaboration with Jerry Silver revealed that CSPGs inhibit neurite growth (Exp Neurol. 1990). His lab was first to report that N-cadherin is a potent stimulator of oligodendrocyte maturation. Since coming to Miami he has studied axon regeneration.
Education & Training
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Research InterestsNeuroplasticity/Neuroregeneration<br>High Content Analysis, deep sequencing & informatics, tissue clearing, fluorescent light sheet microscopy / ultramicroscopy<br><br>We use High Content Analysis to test thousands of genes and compounds on various primary neurons in culture to identify those that can promote or inhibit axon growth and regeneration. We use information theory and artificial intelligence approaches to identify targets.<br><br>We use RNASeq to uncover mRNAs and miRNAs relevant to axon regeneration. We are especially interested in transcription factors as tools to promote regeneration and use bioinformatic tools to uncover them.<br> <br>To test hits from our in vitro screens we use models of spinal cord injury and optic nerve crush.<br><br>We work on ontology development and BD2K projects with Stephan Schürer, PhD in the Center for Computational Sciences and Ubbo Visser, PhD in Computer Sciences on the Bioassay Ontology project, the BD2K LIFE project, and the RegenBase project.
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