Distinguished Leonard M. Miller Professor
Distinguished Medical Research Scientist, VAMC
Head, Endocrine Polypeptide and Cancer Institute, VAMC
Research InterestsDevelopment and evaluation of peptide analogs with antitumor activity including targeted cytotoxic analogs of LHRH, somatostatin and bombesin and antagonistic analogs of GHRH Inhibitory effects of peptide analogs on various cancers, including prostate cancer, pancreatic cancer, gastric cancer, colon cancer, malignant brain tumors, lung cancer (SCLC and non-SCLC), renal cancer and osteosarcomas, melanomas, hepatocellular carcinoma and lymphomas as well as breast cancers, ovarian cancers and endometrial cancers. Mechanism of action of GHRH antagonists and its receptors. Mechanism of action of LHRH antagonist Cetrorelix on BPH. Evaluation of hypothalamic peptide analogs in cardiology, diabetic nephropathy and Alzheimer's disease.