Dr. Bradley Goldstein Receives Research Grant to Study Olfactory Loss

Bradley Goldstein, M.D., Ph.D., associate professor of otolaryngology, is a new recipient of a Clinician/Scientist Development Award from the Triological Society and the American College of Surgeons, supporting his research on olfactory loss. The grant is designed to augment the research programs of promising clinician/scientists who are currently supported by National Institutes of Health career development awards, in an effort to help them compete for further NIH funding. The new award provides an additional $80,000 a year for three years.

Goldstein’s research is aimed at understanding the contribution of stem cells to neurogenesis and tissue homeostasis in the olfactory system. He and collaborators at the Interdisciplinary Stem Cell Institute and the Department of Physiology and Biophysics have published their recent findings in the journal Development. This paper reports a novel method for the culture of olfactory stem cells, and also explores previously unrecognized regulatory mechanisms involved in their self-renewal.

Using animal models and cell culture approaches, the research is aimed at identifying strategies to prevent loss of olfactory sensory cells, or to promote their regrowth in conditions in which they are damaged.

“Head injury, viral infection, or inflammatory conditions such as chronic sinusitis can lead to a loss of smell, and current treatment options are limited,” Goldstein said. “Understanding the mechanisms involved in the generation of olfactory neurons is an important step in the potential development of new treatments.”

The grant will boost productivity and aid in expansion of the lab, he added.

Otolaryngologists/head and neck surgeons commonly see patients with smell or taste disorders. Goldstein’s clinical practice is at the Department of Otolaryngology in the Don Soffer Clinical Research Center, and also through Jackson Memorial Hospital.

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